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A random effects regression model was used to pool research outcomes. This regression method assumes that included research will produce different effect sizes for outcomes, and that these effect sizes are normally distributed (Riley Reference Riley, Higgins and Deeks2011; Deeks Reference Deeks, Higgins, Altmann, Higgins, Thomas and Chandler2022). In the present study, we used linear regression evaluation to unequivocally assess the anticonvulsant potential of modafinil, its sulfone, and acid metabolites and GBR within the MEST take a look at in mice. Intraperitoneal injection of the DAT blocker GBR 12909 at 25 mg kg−1 had similar results on the activity of all tested AEDs. Modafinil and its metabolites at the subprotective dose of fifty mg kg−1 (the dose that by itself didn’t significantly enhance the threshold for electroconvulsions) potentiated the anticonvulsant exercise of CBZ, PHT, and VPA towards MES-induced seizures in mice. Contemplating the outcomes from our research (based on the TID20 values as determined within the MEST take a look at), it is surprising that a earlier study reported modafinil administered alone in a dose of 300 mg kg−1 (i.p.) exerts 100 % safety towards MES-induced seizures, while sulfone and acid metabolites of modafinil utilized in the same dose protects 50 and 0 % of animals in the screening mouse MES check, respectively (Chatterjie et al.